An Introduction to Nutrigenetics, Nutrigenomics and Pharmacogenomics
Online course includes a combination of guided self-study, estimated to be 18 hours, plus 6 recorded online Q&A sessions (totalling 9 hours webinars) with the dnalife® educators.
Practitioner education is key to the incorporation of genetic testing into clinical practice. This online dnalife® education course will help equip you with the necessary knowledge to translate DNA test results into practical nutritional and lifestyle solutions, essential for the responsible integration of DNA testing into clinical practice. Become a dnalife® Accredited Practitioner and be part of our global network.
You will be introduced to the concept of nutrigenetics and nutrigenomics and applying this science in practice. The course provides important information around the genes and underlying principles of our core DNA tests, increasing your understanding and confidence to use these tests in your practice.
Modules Included:
Introduction to Genetics
DNA Health: Genetics of key biochemical processes governing health & disease (Lipid Metabolism, Methylation, Inflammation, Oxidative stress, Detoxification, Bone Health, Insulin Resistance, Food responsiveness, Vitamin Metabolism)
DNA Oestrogen: Key biochemical processes governing Oestrogen Metabolism
DNA Diet: Genetics of Weight Management
DNA Sport: Genetics of Exercise Performance
DNA Mind: Genetics and Mental Health
Medcheck: Pharmacogenomics
Multiple choice questions to be completed after each Module.
CPD accredited.
Healthcare Practitioners will be accredited with dnalife® upon completion of this course and will be able to use the dnalife® tests in their practice as well as become part of our referral network.
Language: English
The Educators:
Helen Gautschi, RD
Sasha Maggs, MSc (Med) Hum Gen
Jessica Pieterse, RD
Overview
Tests for:
Gene variations associated with metabolic and biological processes
Analytes measured:
Lipid Metabolism
LPL: Removes lipids from the circulation by hydrolysing triglycerides into free fatty acids.
CETP: Plays a key role in the metabolism of HDL and mediates the exchange of lipids between lipoproteins.
APOC3: Plays an important role in cholesterol metabolism.
APOE: Is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Affects antioxidant requirement.
B Vitamins/Methylation
MTHFR: Directs folate from the diet either to DNA synthesis or homocysteine re-methylation.
MTR: Catalyses the re-methylation of homocysteine to methionine.
COMT: Catalyses the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine.
MTRR: Catalyses methylcobalamin, which is essential for maintaining adequate intracellular pools of methionine. It is also responsible for maintaining homocysteine concentrations at non-toxic levels.
CBS: Catalyses the conversion of homocysteine to cystathionine and is directly involved in the removal of homocysteine from the methionine cycle.
Detoxification
CYP1A1: The cytochrome P450 enzyme converts environmental pro-carcinogens to reactive intermediates, which are carcinogenic.
GSTM1: Influences Phase II detoxification. It is responsible for the removal of xenobiotics, carcinogens, and products of oxidative stress.
GSTP1: Influences the metabolism of many carcinogenic compounds.
GSTT1: A member of a super family of proteins that catalyses the conjugation of reduced glutathione.
NQO1: Quinone Reductase is primarily involved in the detoxification of potentially mutagenic and carcinogenic quinones derived from tobacco smoke, diet and oestrogen metabolism.
Inflammation
IL-6: Plays a crucial role in inflammation by regulating the expression of C reactive protein (CRP).
TNF-A: TNFa is a pro-inflammatory cytokine, secreted by both macrophages and adipocytes, which has been shown to alter whole body glucose homeostasis, and has been implicated in the development of obesity, obesity-related insulin resistance and dyslipidemia.
Food Responsiveness and Sensitivity
MCM6: Associated with adult hypolactasia.
FADS1: Influences blood fat concentrations by affecting desaturase enzyme efficiency.
CYP1A2: This detoxification enzyme influences the ability to metabolise caffeine.
ACE & AGT: Part of the renin-angiotensin system and response to salt.
HLA DQ2/DQ8: Major genetic predisposition for coeliac disease
Vitamin Metabolism
BC01: Catalysing carotenoids to retinal (vitamin A)
CYP2R1: Conversion of vitamin D to 25(OH)D
FUT2: Vitamin B12 absorption and transport
GSTT1: Contributing to glutathione-ascorbic acid (vitamin C) antioxidant cycle
Iron Overload
HFE: Regulates iron absorption by regulating the interaction of the transferring receptor with transferrin. Hereditary haemochromatosis results from defects in the HFE gene.
Oxidative Stress
eNOS: Influences vascular tone and peripheral vascular resistance. It also has vaso-protective effects by suppressing platelet aggregation, leukocyte adhesion and smooth muscle cell proliferation.
MnSOD/SOD2: Has vital anti-oxidant activity within the cell, especially within the mitochondria. It destroys the radicals that are normally produced within cells.
Bone Health
VDR: Has a profound influence on bone density.
COL1A1: Influences the ratio of collagen-alpha chains produced by bone cells, affecting bone mineralisation of bone and bone strength.
Insulin Sensitivity
PPARG: Involved in adipocyte differentiation. It is a transcription factor activated by fatty acids, and is also involved in the regulation of glucose and lipid metabolism.
TCF7L2: Influences blood glucose homeostasis – both insulin secretion and resistance.
FTO: Influences susceptibility to obesity and risk for type 2 diabetes.
SLC2A2: Facilitates glucose induced insulin secretion and is involved in food intake and regulation.
Practical
Test type:
DNA: Gene, health, nutritional genomics, pharmacogenomics
Sample required:
Buccal swab
Average processing time:
18-21 days